Evidence-conscious biohacking
Explore the science behind modern human performance, cognition, metabolism and longevity. Every card answers four questions — and shows how strong the evidence really is.
Levels describe evidence for one specific outcome, not an overall grade for an ingredient. Citations last reviewed 2026-11-01.
THE FOCUS EQUATION
Attention, alertness and drive are shaped first by sleep, light, food and stress — compounds are studied on top of that.
LEVEL B Attention when combined with caffeine (short lab tasks)
LEVEL C Relaxation / alpha-wave EEG activity on its own
LEVEL C Cognition under acute stress or heavy demands
LEVEL D Cognition in rested, unstressed people
Requires professional review with MAO-inhibitor antidepressants, thyroid conditions or levodopa.
LEVEL B Attention-switching and alertness, acute
LEVEL E Long-term cognitive benefit
Late-day caffeine disrupts sleep architecture.
RESEARCH, NOT RECOMMENDATIONS
PROPOSED COMPLEMENTARITY — NOT PROVEN SYNERGY
Scientific rationale
Pairing a compound studied for relaxed attention with a catecholamine precursor is biologically interesting.
Individual mechanisms
Theanine: alpha-wave/attention research. Tyrosine: dopamine & noradrenaline synthesis.
Direct human combination evidence
No robust direct human trial of this specific combination was found.
Individual-ingredient evidence
Each ingredient has small human studies (theanine mostly with caffeine; tyrosine under stress).
Animal / mechanistic evidence
Mechanistic plausibility only.
What is not known
Whether they complement, cancel or do nothing together.
Safety considerations
MAO inhibitors, thyroid conditions, levodopa, anxiety disorders.
Question for professional review
Is my cognitive problem actually sleep, stress or workload?
Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands — a review
Jongkees BJ, Hommel B, Kühn S, Colzato LS · Journal of Psychiatric Research 2015 · Narrative review · Healthy and clinical populations under acute demands
Tested: Oral L-tyrosine → Cognition under stress (cold, noise, sleep loss, multitasking). Limitations: Heterogeneous small studies; benefits mainly when demands are high
PMID 26424423THE LONGEVITY FRONTIER
A case study of Bryan Johnson's publicly documented Blueprint protocol. BQCO is not affiliated with, or endorsed by, Bryan Johnson or Blueprint, and this is not a recommendation to follow it.
What is publicly documented
What has human evidence
Sleep regularity, regular exercise, diet quality and preventive screening each have human evidence for specific outcomes.
What remains experimental
Many of the protocol's supplements, therapies and biomarker targets are experimental, and the overall protocol has not been tested as a whole in a trial.
What is specific to one individual
It is designed around one person's biology, budget, time and medical supervision — and is self-reported.
What BQCO takes from it
The transferable idea is systematic self-observation: measure, change one thing, observe, review. BQCO's 28-day framework uses that idea — at your scale.
Source: https://protocol.bryanjohnson.com/, retrieved 2026-11-01. Supplement lists change over time and are intentionally not reproduced.
BQCO plans can conclude that a simpler stack — or no additional supplement — is the best outcome.